|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These are the first results indicating that the O blood group and FUT2 secretor status are protective factors against CD in Asians.
|
31260595 |
2020 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.050 |
Biomarker
|
disease |
BEFREE |
The engineered E. coli constructed previously is able to express fucokinase/GDP-l-fucose pyrophosphorylase (Fkp) from Bacteroides fragilis and the α-1,2-fucosyltransferase (FucT2) from Helicobacter pylori and deficient in β-galactosidase (LacZ), fucose isomerase (FucI), and fuculose kinase (FucK).
|
31145478 |
2019 |
|
Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The engineered E. coli constructed previously is able to express fucokinase/GDP-l-fucose pyrophosphorylase (Fkp) from Bacteroides fragilis and the α-1,2-fucosyltransferase (FucT2) from Helicobacter pylori and deficient in β-galactosidase (LacZ), fucose isomerase (FucI), and fuculose kinase (FucK).
|
31145478 |
2019 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, Fut2-deficient (Fut2<sup>-/-</sup>) mice, which lacked lung epithelial fucosylation, showed significantly attenuated eosinophilic inflammation and airway hyperresponsiveness in house dust mite (HDM)-induced asthma models.
|
31125592 |
2019 |
|
Rotavirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
First, studies of Mendelian resistance to infection have revealed an essential role of DARC-expressing erythrocytes in protection against Plasmodium vivax infection, and an essential role of FUT2-expressing intestinal epithelial cells for protection against norovirus and rotavirus infections.
|
31121434 |
2019 |
|
Birth Weight
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
|
31043758 |
2019 |
|
Viral gastroenteritis due to Rotavirus
|
0.020 |
Biomarker
|
disease |
BEFREE |
In order to evaluate the role of HBGAs in rotavirus infections in our population, secretor status (FUT2+), ABO blood group, and Lewis antigens were determined in children attended for rotavirus gastroenteritis in Valencia, Spain.
|
30974776 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
|
30926973 |
2019 |
|
Toxoplasmosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
FUT3 and FUT2 genotyping and glycoconjugate profile Lewis<sup>b</sup> as a protective factor to Toxoplasma gondii infection.
|
30831115 |
2019 |
|
Respiratory Tract Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Phenotyping of Lewis and secretor HBGA from saliva and detection of new FUT2 gene SNPs from young children from the Amazon presenting acute gastroenteritis and respiratory infection.
|
30790699 |
2019 |
|
Acute gastroenteritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Phenotyping of Lewis and secretor HBGA from saliva and detection of new FUT2 gene SNPs from young children from the Amazon presenting acute gastroenteritis and respiratory infection.
|
30790699 |
2019 |
|
Diarrhea
|
0.140 |
Biomarker
|
phenotype |
BEFREE |
Children of secretor (FUT2 positive) mothers had a 38% increased adjusted risk of all-cause diarrhea (HR = 1.38; 95% confidence interval (CI), 1.15-1.66) and significantly reduced time to first diarrheal episode.
|
30768135 |
2019 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several studies have been conducted to investigate the association of fucosyltransferase 2 gene (rs601338) variant with UC and CD, but the results were inconsistent.
|
30615603 |
2019 |
|
Inflammatory Bowel Diseases
|
0.140 |
GeneticVariation
|
group |
BEFREE |
CONCLUSIONS Fucosyltransferase 2 gene (rs601338) polymorphism is associated with susceptibility to IBD, UC, and CD in the Chinese population, but these results might not be generalizable to other ethnic populations.
|
30615603 |
2019 |
|
Ulcerative Colitis
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Several studies have been conducted to investigate the association of fucosyltransferase 2 gene (rs601338) variant with UC and CD, but the results were inconsistent.
|
30615603 |
2019 |
|
Cardiovascular Diseases
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Biliary calculi
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.
|
30504769 |
2018 |
|
Autoimmune Diseases
|
0.120 |
GeneticVariation
|
group |
BEFREE |
Non-secretor status due to homozygosity for the common FUT2 variant c.461G>A (p.Trp154<sup>∗</sup>) is associated with either risk for autoimmune diseases or protection against viral diarrhea and HIV.
|
30401457 |
2018 |
|
Influenza
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fut2 is transiently upregulated in mouse middle ear after inoculation with non-typeable Haemophilus influenzae.
|
30401457 |
2018 |
|
Otitis Media
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The common FUT2 c.604C>T (p.Arg202<sup>∗</sup>) variant co-segregates with otitis media in a Filipino pedigree (LOD = 4.0).
|
30401457 |
2018 |
|
Viral gastroenteritis
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Non-secretor status due to homozygosity for the common FUT2 variant c.461G>A (p.Trp154<sup>∗</sup>) is associated with either risk for autoimmune diseases or protection against viral diarrhea and HIV.
|
30401457 |
2018 |
|
Recurrent otitis media
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Common and rare FUT2 variants confer susceptibility to otitis media, likely by modifying the middle ear microbiome through regulation of A antigen levels in epithelial cells.
|
30401457 |
2018 |
|
Infectious Otitis Media
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The common FUT2 c.604C>T (p.Arg202<sup>∗</sup>) variant co-segregates with otitis media in a Filipino pedigree (LOD = 4.0).
|
30401457 |
2018 |
|
Diarrhea
|
0.140 |
GeneticVariation
|
phenotype |
BEFREE |
For FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhea during ages 6-12 months and ages 12-24 months per additional risk (G) allele were 1.23 (95% confidence interval [CI], 1.08-1.4; P = .002) and 1.41 (95% CI, 1.24-1.61; P = 1.7 × 10-7), respectively; the risk ratio for ≥1 diagnosis of a lower respiratory illness (ie, pneumonia or bronchiolitis) during ages 12-24 months per additional G allele was 2.66 (95% CI, 1.64-4.3; P = .00007).
|
30376117 |
2019 |
|
Bronchiolitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhea during ages 6-12 months and ages 12-24 months per additional risk (G) allele were 1.23 (95% confidence interval [CI], 1.08-1.4; P = .002) and 1.41 (95% CI, 1.24-1.61; P = 1.7 × 10-7), respectively; the risk ratio for ≥1 diagnosis of a lower respiratory illness (ie, pneumonia or bronchiolitis) during ages 12-24 months per additional G allele was 2.66 (95% CI, 1.64-4.3; P = .00007).
|
30376117 |
2019 |